Fluorometric analysis of emetine hydrochloride

Continuous Eructations Treated by Emetine Hydrochloride

Phase I Experience with Emetine Hydrochloride ( Nsc 33669 ) As

This report details a Phase I dose-ranging experiment of the use of emetine in patients with a variety of malignant diseases. The data show that emetine can be given intravenously a t 4-day intervals with minimal toxicity. Severe muscle weakness, the most important dose-limiting toxic effect, began a t approximately a 15 mg/kg cumulative dose level and resulted in discontinuance of therapy i n ...

Emetine hydrochloride and chloroquine in the treatment of children with amoebic liver abscess.

Although amoebic liver abscess is infrequent in children, the outcome is much less favourable than it is in adults. When treated with combined emetine hydrochloride, chloroquine, and aspiration, the prognosis is excellent in adults (Wilmot, 1962), this regime being more successful than treatment with a single drug (Wilmot, Powell, and Adams, 1959; Wilmot, Powell, MacLeod, and Elsdon-Dew, 1964)....

Biological Activities of Emetine

Emetine is a natural product alkaloid from ipecac species. It is one of the main active ingredients in ipecac syrup used as emetic, and has been used extensively in phytomedicine as an antiparasitic drug. It inhibits both ribosomal and mitochondrial protein synthesis and interferes with the synthesis and activities of DNA and RNA. For this reason, it has been a vital tool to pharmacologists and...

Semi-solid surface fluorometric analysis of glucose.

We describe an enzymatic fluorometric method for determining glucose concentrations in blood samples by analysis on a semi-solid surface (silicone-rubber pads). The method is an adaptation of existing spectrophotometric procedures based on the sequential coupling reactions with glucose-6-phosphate dehydrogenase and NADP+. The rate of appearance of NADPH fluorescence at 460 nm (excitation wavele...